
NYPD detectives of the Major Case Squad use unconventional methods to solve crimes. Like its predecessor, the original "Law & Order," its storylines are often based on real-life headlines, and it features a cadre of quirky cops whose mission it is to find the criminals and make them pay.

When a recipient of an organ transplant is murdered, the seemingly altruistic donor becomes the detectives' prime suspect.

When a woman is found murdered in a fashion that matches the modus operandi of a series of unsolved murders 16 years ago, the detectives suspect that the killer has resurfaced.

The murders of a couple in witness protection point the detectives to people the victims were to testify against, but attention turns to the daughter's biological father.

When a woman dies from a form of dioxin poisoning, Detectives Goren and Eames investigate a list of likely suspects, including the woman's husband, a busy dentist (Bronson Pinchot).