
World's Most Evil Killers delves straight into the stories of the world's most prolific killers. Each episode focuses on one notorious killer and features first-hand accounts of their behavior; such killers range from Fred and Rose West, Ed Gein, the Clown Killer, to the Milwaukee Cannibal. Accounts are also given by detectives who ran the cases, journalists who reported on them, relatives, experts on analysis, and sometimes even survivors.

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A serial killer brutally snatches away the lives of eight innocent women during a decade-long killing spree in Louisiana.
Douglas Clark and Carol Bundy were a deadly duo who terrorized the streets of Los Angeles in the summer of 1980, targeting vulnerable women, teenagers and even a child.
Keith Jesperson, known as the Happy Face Killer, killed eight women across several states in the 1990s.
In December 1998, The Railroad Killer, 38-year-old Angel Reséndiz brutally beat Dr. Claudia Benton to death in her own home; he's suspected of murdering at least nine more people; he evades authorities by using a multitude of aliases.