
World's Most Evil Killers delves straight into the stories of the world's most prolific killers. Each episode focuses on one notorious killer and features first-hand accounts of their behavior; such killers range from Fred and Rose West, Ed Gein, the Clown Killer, to the Milwaukee Cannibal. Accounts are also given by detectives who ran the cases, journalists who reported on them, relatives, experts on analysis, and sometimes even survivors.

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Responsible for five murders, Joshua Wade avoided justice for years and later confessed to killings that started from when he was just 14.
Douglas Clark and Carol Bundy were a deadly duo who terrorized the streets of Los Angeles in the summer of 1980, targeting vulnerable women, teenagers and even a child.
The story of the Beltway sniper attacks; John Allen and his teenage accomplice carry out a brutal series of shootings that kill ten people.
In 1999 and 2000, John Eric Armstrong cruised the streets of Detroit, Mich., looking for sex workers; seen as an ordinary husband, father and co-worker, no one in Armstrong's life suspected that he was a serial killer.