
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Detectives learn that a genetic disorder caused the deaths of a woman's children, resulting in an overturned conviction.

The murder of a young Seattle couple puzzles investigators until the victims' dog, Chief, leads police to the killer.

Investigators reopen a case from 1984 involving the rape of a young Virginia woman when DNA testing refutes her identification of the rapist and calls everything into question, leading to the accused person's exoneration.

A handsome young doctor's fiancée experiences severe illness after revealing that she is pregnant, and launches her own investigation to determine if the doctor is somehow responsible.