
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A woman heads home after church, but never makes it there alive, triggering a homicide investigation.

The apparent suicide of Dr. Darryl Sutorius, a respected heart surgeon, is questioned when an investigation reveals his new wife's violent history.

Volunteers and police spend weeks searching for a missing girl. A psychic later leads them to a field where the body was found.

San Diego police investigate the murder of a missing person whose hands turn up in a dumpster; an anonymous letter, containing details only the killer would know, offers clues to solving the case.