
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A church member gets gunned down after leaving choir practice; although witnesses see little and not much evidence exists, investigators learn that she had been having affairs for years.

When a sexual predator murders two young boys in Nebraska, an obscure style of rope and forensic analysis lead to his arrest and conviction.

A young bride-to-be is gunned down in her own home. The attack is personal and as investigators start digging, they uncover the man she loved was living a lie.

Police exhume the body of Karla Brown, murdered in her home in 1978, to study bite wounds, which eventually lead to the killer.