
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Physical evidence initially condemns a prime suspect to a double homicide, but DNA from a discarded spoon points to another.

In Lorton, Va., police attempt to determine who abducted 5-year-old Melissa Brannen after she disappeared from a Christmas party, but cannot be certain until they match hair from a rabbit-fur jacket Brannen wore that day.

A young girl falls ill and dies; forensic investigators search for evidence halfway around the world to shed light on the tragic death.

A husband confesses to his wife's murder, only to be found not guilty a year later when a phone tip and forensic evidence point to another.