
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A woman is found dead on her bedroom floor, the only clue is a bloodstained sheet; breakthrough forensics enable police to identify the killer.

The murder of 53-year-old Paul Gruber is examined, and the evidence points to Darryl Robin Kuehl, who was later convicted of the crime.

A young man is killed in a mysterious car crash, but the evidence at the scene lead investigators to believe it is not an accident; forensic science reveals what really happens, and the truth devastates three families.

How the bombs were made leads investigators in Colorado to find the perpetrator.