
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Investigators see through a killer trying to cover his tracks by staging the crime scene to learn what really happened.

When a man dies unexpectedly in the office of a noted California doctor, police begin what they think will be a routine investigation, but discoveries of false identities and insurance fraud raise questions about the doctor's role.

A young girl beaten after watching her grandmother killed, identifies the wrong person; years later she tries to change her statement.

A mother puts her hope on the internet and an independent investigation to clear her name after authorities charge her with murdering her 17-month-old son in a fire considered to be intentionally set.