
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

After a Michigan State University grad student disappears and is presumed dead, a professor of geological sciences helps police get the dirt on her killer.

The apparent suicide of Dr. Darryl Sutorius, a respected heart surgeon, is questioned when an investigation reveals his new wife's violent history.

A woman gets shot in her driveway; she may have been the victim of a co-worker half her age that she had recently rejected.

A pair of tennis shoes are found near a victim who had been stabbed on the beach, less than ten yards from her hotel.