
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

When a Pennsylvania man checks into a hospital for leg pain and later dies of thallium poisoning, police investigate his wife and find her in the process of collecting an insurance payment for her previous husband's death.

Emergency dispatch received a call from a man who said his girlfriend shot and killed herself. But the wound was not self-inflicted.

While at a real estate conference in St. Louis, a man finds his wife drowned in the bathtub in their hotel room.

Investigators piece together evidence found at the scene of a Native American woman's murder; the tire tracks and shoe impressions could lead them to the killer.