
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Hikers near Anchorage, Alaska discover a body wrapped in sheets edged in orange stitching; they discover threads of evidence clinging to the sheet.

A police officer claims his estranged wife's shooting death was a suicide, but investigators think it was a murder.

A woman disappears without a trace, and police learn two other women vanished under similar circumstances.

When firefighters find a family dead inside their home, it appears to be a murder-suicide; clues at the scene lead investigators to believe otherwise.