
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

When 4-year-old April Renee Tucker is found dead in her backyard, her parents tell the police that neighborhood dogs attacked and killed her, but the injuries on her body don't match their account of what happened.

With a long list of suspects, forensic experts agree on one thing in this brutal murder: the killer knew his victim.

One year after Maine resident Pearl A. Bruns' disappearance, forensic technology helps to find her body and determine who was responsible for her death.

The only lead to finding a serial killer on the loose is a bloody fingerprint on the body of a victim.