
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

With children dying at an alarming rate at a Texas hospital, authorities narrow down their probe to one nurse, but the murder weapon remains elusive.

A man is found stabbed to death after a night in a strip club; a drop of blood on a bedspread becomes critical evidence five years later.

Police charge Alan "The Zenith Man" Ridley with murdering his wife, Virginia, but following an autopsy, medical detectives believe he may not have killed his wife after all.

A young girl is found dead, the victim of an apparent sex killer; there are few clues to the killer's identity, but authorities are intrigued by unusual orange fibers embedded in clothing found near the victim.