
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

The investigation into the disappearance of flight attendant Helle Crafts leads to the murder conviction of her pilot husband.

When a young doctor is accused of sedating and sexually assaulting two of his female patients, DNA tests show him to be innocent, but the women persist with their claims; seven years later, a private investigation leads to a surprising discovery.

Old-fashioned police work and computer animation determine how a 15-year-old boy was shot while inside a Dallas gun club.

When a fundamentalist group is accused of robbing banks, authorities know they are dealing with experienced criminals and overwhelming evidence, but the defense is very well-funded.