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Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.
S1, EP4 "The Footpath Murders"
Scientists and detectives use DNA to solve a string of rapes and murders.
S1, EP13 "Raw Terror"
An 11-year-old boy comes down with a fever and diarrhea after eating an undercooked burger; when his condition worsens, his mother drives him to a hospital and doctors discover E. coli destroying his body.
S6, EP29 "Treading Not So Lightly"
A mother is determined to discover what happened when her daughter is injured in a hit-and-run accident.
S4, EP3 "Ultimate Betrayal"
A 1995 fire razes the mansion of a Kansas doctor, killing two of her three children; disturbing accounts from an ex-husband lead investigators to believe the doctor set the blaze herself.
S14, EP21 "Expert Witness"
A killer assaults a young mother in her home, but despite meticulous washing of the crime scene, a single hair remains to lead authorities to the culprit.
S14, EP20 "Funeral Services"
Police discover a mask near the crime scene and hope that it leads to the killer of a funeral director.
S14, EP19 "Skeleton Key"
A woman goes missing for a month with the only clues being a set of keys, a fingerprint and a code.
S14, EP17 "Seeing Red"
A body is found stuffed into a suitcase forcing the police to search though the landfill for another missing victim.