
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

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A mother and her two young daughters are found brutally murdered and sexually violated; the crime scene has no shortage of evidence, but investigators cannot find a conclusive link to their prime suspect.
A woman's body is found inside a burned mobile home and the autopsy reveals she was beaten, making this a murder.
When a policeman's home burns to the ground, he later arrests a man who confesses to arson, but the confession seems dubious.
Security guard who disappeared from his post was found a year later in a remote camp site; a decade later, a phone call and a paint smear on his boot helped scientists determine what happened during his final moments.