
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

When a single mother is murdered, her brother vows to find the person responsible for the death of his sister, even if it takes more than 30 years.

When an English couple go missing, police suspect their son killed them and must rely on mud and blood samples found in the couple's two cars to find their bodies.

Police investigate a young woman found murdered two weeks after reporting a road rage incident; evidence leads not to the aggressive driver, but one of their own.

Experts attempt to discover the source of heavy fog on Highway I-75 in Tennessee, which caused a 99-car accident and 12 deaths.