
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

When a 62-year-old man opens a car restoration business and becomes seriously ill, his doctors cannot find the cause, but forensics can; identification of a highly toxic metal in the victim's blood leads to his poisoner.

Investigators use obscure evidence to find the person responsible for killing justice officials with mail bombs in the South.

Forensic scientists provide authorities with evidence that a death deemed accidental 20 years ago was actually murder.

A family suspects their teenage daughter's new friends were involved in her disappearance.