
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Evidence that includes threatening emails, a missing person and an abandoned truck lead police to a woman's suspected killer, but they don't have the victim's body.

A mother claims that an intruder murdered her two sons, but lacking a motive, police use blood-spatter analysis and behavioral profiling to reconstruct a different scenario.

After years of suffering domestic abuse, a young woman is found murdered in her bathtub; among numerous clues, a hamburger bun proves the most incriminating.

A 1995 fire razes the mansion of a Kansas doctor, killing two of her three children; disturbing accounts from an ex-husband lead investigators to believe the doctor set the blaze herself.