
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Three seemingly unrelated deaths proved to be serial murders; the killer had been careful, he used poison which had no taste or odour; fortunately for investigators, it also has a unique chemical signature.

The violent death of an Air Force officer's wife outside a Philippines air base is examined, amid accusations of a love triangle involving the murdered woman's husband; investigators use groundbreaking computer forensics to make their case.

Investigators on both sides of the Atlantic seek links between three homicides that look like professional executions.

At first glance it appears a young woman suffocated, but further investigation shows the scene was staged.