
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Three seemingly unrelated deaths proved to be serial murders; the killer had been careful, he used poison which had no taste or odour; fortunately for investigators, it also has a unique chemical signature.

Detectives find suspicious similarities when a husband and wife report their second daughter missing a few years after the disappearance of their first.

A man is murdered in his sleep but no fingerprints are anywhere to be found; a shoe impression outside could lead to the killer.

Police exhume the body of Karla Brown, murdered in her home in 1978, to study bite wounds, which eventually lead to the killer.