
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A man kills two people with bombs in an effort to get investors off his back, but authorities catch onto him, and he becomes sentenced to life with no chance of parole.

Technology able to analyze human bite-marks yields information on a woman's death.

Heavy rains and snow run-off carry manure into Milwaukee's water supply in 1993, leading to an epidemic of gastrointestinal illness affecting 400,000 people.

A death in Pennsylvania is strikingly similar to one in North Carolina.