
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.
Investigators reopen a case from 1984 involving the rape of a young Virginia woman when DNA testing refutes her identification of the rapist and calls everything into question, leading to the accused person's exoneration.
A speck of bicycle paint and a speck of nickel left over from a collision with a twice-convicted child molester's car provide critical clues in the murder of a 9-year-old.
A 2-year-old boy's brain seizures and breathing problems baffle doctors until they learn the mother exhibits signs of Munchausen syndrome by proxy, a rare condition that led her to physically abuse her son and contributed to her daughter's death.
Two years after an 18-year-old's murder in Albion, Mich., a tiny drop of blood and burned bones lead police to her killers.