
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.
Experts attempt to discover the source of heavy fog on Highway I-75 in Tennessee, which caused a 99-car accident and 12 deaths.
When a woman goes missing from her home, police focus on her husband when an airline luggage tag and luminol point to an affair and murder; footage from a TV crew and Coast Guard photographs lead investigators to the suspect's missing boat.
When a woman exhibits strange flu-like symptoms before dying, investigators discover someone added thallium to her soda; detectives initially suspect her husband, but the case takes a sinister turn.
When dozens of infants develop serious breathing problems in the Cleveland area, doctors and investigators search high and low for the cause.