
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

The apparent suicide of Dr. Darryl Sutorius, a respected heart surgeon, is questioned when an investigation reveals his new wife's violent history.

Volunteers and police spend weeks searching for a missing girl. A psychic later leads them to a field where the body was found.

San Diego police investigate the murder of a missing person whose hands turn up in a dumpster; an anonymous letter, containing details only the killer would know, offers clues to solving the case.

Forensic investigators try to stop a killer who is apparently responsible for two slayings in a community in South Carolina.