
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A mother and her two young daughters are found brutally murdered and sexually violated; the crime scene has no shortage of evidence, but investigators cannot find a conclusive link to their prime suspect.

Security guard who disappeared from his post was found a year later in a remote camp site; a decade later, a phone call and a paint smear on his boot helped scientists determine what happened during his final moments.

When a policeman's home burns to the ground, he later arrests a man who confesses to arson, but the confession seems dubious.

When three students are brutally murdered close to campus, investigators must determine what the women had in common before their serial killer strikes again.