
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

When a young doctor is accused of sedating and sexually assaulting two of his female patients, DNA tests show him to be innocent, but the women persist with their claims; seven years later, a private investigation leads to a surprising discovery.

Officials probe the death of a woman investigating the possible side effects of the drug she was prescribed for bipolar disorder.

The search for the killer of two teenagers in Texas shows a behavioral study on how most serial killers also have a history of abusing animals.

A child's memory, a diary and a forensic psychologist help investigators solve a young woman's murder.