
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

The light of day and DNA picture painted by molecular biologist reveals new clues about a nighttime traffic accident.

The derailment of the Sunset Limited was the deadliest train crash in U.S. history killing 47 passengers and crew with several more injured.

A discarded sleeping bag, containing bloody sneakers and a purse, leads police to the body of a young woman; a mark found on the victim's body enables police to track the killer.

An irrigation canal murder remains unsolved until a similar murder occurs.