
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A seemingly model citizen turns out to be a serial killer.

A fire, caused by an unattended cigarette, kills the estranged wife of a police officer; forensic scientists discover that the cause is far more complicated.

An abandoned, still-running car leads investigators to a body with unusual marks and a DNA trail that lead to the killer.

A news anchor is shot to death outside her home in an apparent crime of passion by a fan; a police dog tracks the scent of the killer back to the crime scene.