
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

In a wealthy area of Philadelphia, police are called to the scene of what seems like a regular accidental drowning; the investigation begins to focus on one person who has many reasons to want the victim dead.

The robbery and brutal murder of an elderly couple goes unsolved for 10 years; a forensic scientist makes history when he solves the crime.

A 19-year-old girl is found dead in her car in what appears to be a suicide; police discover that the victim was involved in a love quadrangle, giving several people motive to kill.

Police suspect a gay college student's slaying is a hate crime until forensic evidence points the case in another direction.