
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Teenager is found half-naked with her throat slit; a single foreign hair found on her thumb may finger the killer.

Handwriting and simple doodles complicate a car-bomb case and an alleged self-defense shooting in a peaceful British farming village as police uncover a husband's plot to kill his wife for insurance money.

A bullet-riddled car, a missing driver, and no witnesses, an ambush or a random attack; the clue was something so tiny, it was measured in millionths of a meter.

When dozens of infants develop serious breathing problems in the Cleveland area, doctors and investigators search high and low for the cause.