
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Who put a bomb in the home of a 29-year-old woman and killed her?

Two years after an 18-year-old's murder in Albion, Mich., a tiny drop of blood and burned bones lead police to her killers.

A killer tried to destroy everything which could link them to the crime; but in doing so, they inadvertently created new forensic evidence, evidence which came to light using a technique never before used in a criminal investigation.

A 2-year-old boy's brain seizures and breathing problems baffle doctors until they learn the mother exhibits signs of Munchausen syndrome by proxy, a rare condition that led her to physically abuse her son and contributed to her daughter's death.