
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

After American Atheists founder Madalyn Murray O'Hair disappears, the discovery of a mutilated body helps police catch the culprit.

An Ohio woman and her two daughters go missing while vacationing in Florida; their corpses are found floating in Tampa Bay with a handwritten note by one of the victims; putting it on five billboards helps them find the killer.

Four young adults are murdered in an affluent Texas neighborhood, with little evidence but two people walking by dressed in black.

The murder of a young Seattle couple puzzles investigators until the victims' dog, Chief, leads police to the killer.