
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

When a single mother is murdered, her brother vows to find the person responsible for the death of his sister, even if it takes more than 30 years.

There was no apparent reason for the young, healthy college student to be dead; but when the medical examiner found the tiniest of clues during the autopsy, investigators were able to unravel the mystery of betrayal and revenge.

Police investigate a young woman found murdered two weeks after reporting a road rage incident; evidence leads not to the aggressive driver, but one of their own.

A woman is stabbed a hundred times and her body positioned in a suggestive manner. This could be a hate crime against women.