
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Officials probe the death of a woman investigating the possible side effects of the drug she was prescribed for bipolar disorder.

A two-man shrimp boat sinks when a fast-moving, violent storm struck the Louisiana coast; a deckhand is considered a hero for trying to save the drowned captain, until his body is found.

A chip of stainless steel brings a killer to justice 20 years after a woman's body is found in a ravine.

California police in 1957 search for a murderer, but the case goes cold; 50 years after a crime is committed, advances in computer technology determine the killer.