
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

The derailment of the Sunset Limited was the deadliest train crash in U.S. history killing 47 passengers and crew with several more injured.

A seemingly model citizen turns out to be a serial killer.

A fire, caused by an unattended cigarette, kills the estranged wife of a police officer; forensic scientists discover that the cause is far more complicated.

An abandoned, still-running car leads investigators to a body with unusual marks and a DNA trail that lead to the killer.