
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A husband was shot and killed, forensic psychiatry helped the wife to remember the details for what happened.

When a 62-year-old man opens a car restoration business and becomes seriously ill, his doctors cannot find the cause, but forensics can; identification of a highly toxic metal in the victim's blood leads to his poisoner.

A missing bank president's body is found floating in a lake; the duct tape used in binding him to a chair helps solve the crime.

When a 6-year-old disappears, her father becomes the prime suspect; he fails a polygraph test and even confesses, but 10 years later, the investigation gets turned on its head.