
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Ten years after the murder of a rock singer, forensic scientists use evidence collected to finally bring her killer to justice.

The 1992 hit-and-run death of 6-year-old Nicole Rae Walker leads to a groundbreaking trial as experts submit a video reconstruction of the incident, implicating a drunk driver and demonstrating the viability of video testimony.

After a Michigan State University grad student disappears and is presumed dead, a professor of geological sciences helps police get the dirt on her killer.

The apparent suicide of Dr. Darryl Sutorius, a respected heart surgeon, is questioned when an investigation reveals his new wife's violent history.