
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

After more than 20 people on a Native American reservation die suddenly from a flu-like disease, Navajo medicine men provide a clue that leads to a most unlikely killer.

Three years later, a second autopsy determines who's right when a medical examiner and detectives disagree on the cause of death.

A woman who survived a deadly childhood fire sends police a letter charging that her father killed her mother 30 years ago.

Hit-and-run boating accident that kills a popular young man causes investigators to search for one boat out of thousands.