
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

An investigation into the disappearance of a young woman uncovers a tooth that helps police solve a crime without a body.

Investigators reopen a case from 1984 involving the rape of a young Virginia woman when DNA testing refutes her identification of the rapist and calls everything into question, leading to the accused person's exoneration.

A garbage bag leads police to a child's killer.

A speck of bicycle paint and a speck of nickel left over from a collision with a twice-convicted child molester's car provide critical clues in the murder of a 9-year-old.