
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

While at a real estate conference in St. Louis, a man finds his wife drowned in the bathtub in their hotel room.

Detectives use a forged signature to find a woman's abductor.

A cunning serial rapist who leaves no decisive evidence forces investigators to rely on geographical profiling in their search for an identity; DNA from a cigarette butt may provide the final piece of evidence needed to catch the suspect.

When 15 year-old Marlene Miller was murdered, it would take 24 years and several retrials before forensic scientists discovered the evidence to bring her killer to justice.