
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

In a series of murders near Sacramento, Calif., a killer gags and molests prostitutes, cuts their clothes in random patterns and cuts off their hair; microscopic evidence helps solve the case.

A man calls for help when his wife has a fatal fall down the stairs; numerous amount of bloodstains make police suspicious.

Evidence reveals a teacher who complained of being stalked and harassed by another teacher was scamming police.

A decade old case reopens, and a few seconds of a 911 call enable investigators to determine who is responsible for a murder.