
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Three years later, a second autopsy determines who's right when a medical examiner and detectives disagree on the cause of death.

A man states that a robber shot and killed his wife while they were on the beach, but a song he downloaded makes investigators suspicious.

A woman is found dead on her bedroom floor, the only clue is a bloodstained sheet; breakthrough forensics enable police to identify the killer.

The murder of 53-year-old Paul Gruber is examined, and the evidence points to Darryl Robin Kuehl, who was later convicted of the crime.