
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A young girl is found dead, the victim of an apparent sex killer; there are few clues to the killer's identity, but authorities are intrigued by unusual orange fibers embedded in clothing found near the victim.

After police identify a murder victim thanks to her butterfly necklace, they discover several co-workers had vendettas against the victim.

A money launderer is found dead in the ocean and the only obvious clues to his identity are a Rolex watch and a tattoo; the anchor with which he is weighed down proves most helpful in solving the crime.

The brutal murder of a construction site foreman looks like the work of a disgruntled employee, but forensic science points to an unlikely suspect.