
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

In 1976, 182 war veterans in Philadelphia become hospitalized with pneumonia-like symptoms and 29 die; the disease resurfaces every few years.

Investigators build a makeshift tent around a woman's body and use superglue fumes to lift the killer's palm print from the victim's skin.

Police believe they have a serial rapist and murderer, but DNA testing and research leads to another arrest and conviction.

A jeweler's search through old sales records helps police find likely suspects in the murder of elderly couple Edward Kowalzck and Gertrude Thompson.