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Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?
S5, EP12 "The Shiny Trinket Maneuver"
Amy is upset with Sheldon when he isn't impressed with her recent accomplishment; Howard struggles with Bernadette's aversion to children.
S1, EP17 "The Tangerine Factor"
When Leonard finally works up the courage to ask Penny out on a date, they each turn to Sheldon for advice.
S4, EP13 "The Love Car Displacement"
Bernadette runs into her ex-boyfriend (Rick Fox) while attending a science event with Wolowitz.
S5, EP16 "The Vacation Solution"
Sheldon goes to work with Amy in her neurobiology lab when the university forces him to take a vacation; Bernadette asks Howard to sign a pre-nup.
S12, EP2 "The Wedding Gift Wormhole"
Sheldon and Amy go crazy trying to figure out what "perfect gift" Leonard and Penny gave them for their wedding; Koothrappali decides to settle down and asks his father to arrange a marriage for him.
S12, EP1 "The Conjugal Configuration"
Sheldon and Amy's honeymoon runs aground in New York; Penny and Leonard discover they are uncomfortably similar to Amy's parents; Koothrappali insults physicist Neil deGrasse Tyson and starts a Twitter war.
