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Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?
S6, EP7 "The Habitation Configuration"
Bernadette wants Wolowitz to move out of his mom's house; Sheldon is caught in the middle of Amy and Wil Wheaton's argument.
S6, EP8 "The 43 Peculiarity"
Raj and Howard try to figure out why Sheldon disappears at 2:45 every afternoon; jealousy arises in Penny and Leonard's relationship.
S12, EP1 "The Conjugal Configuration"
Sheldon and Amy's honeymoon runs aground in New York; Penny and Leonard discover they are uncomfortably similar to Amy's parents; Koothrappali insults physicist Neil deGrasse Tyson and starts a Twitter war.
S12, EP2 "The Wedding Gift Wormhole"
Sheldon and Amy go crazy trying to figure out what "perfect gift" Leonard and Penny gave them for their wedding; Koothrappali decides to settle down and asks his father to arrange a marriage for him.
S12, EP6 "The Imitation Perturbation"
When Wolowitz dresses up as Sheldon for Halloween, Sheldon seeks retaliation at Leonard and Penny's Halloween party; Leonard is shocked when Penny doesn't remember their first kiss.