
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

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The gang is concerned when Sheldon's former admirer, Dr. Ramona Nowitzki, resurfaces while Amy is away at Princeton.
Leonard is happy to meet new neighbor Penny, but his roommate thinks he is chasing an impossible dream.
Sheldon and his nemesis, Kripke, compete for a corner office; Penny feels uncomfortable after receiving a gift from Amy.
Sheldon's routine is turned upside down when his barber gets sick; Wolowitz questions his decision to go into space.