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Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?
S12, EP15 "The Donation Oscillation"
Penny tries to throw a wrench into Leonard's plan to be a sperm donor for her ex-boyfriend; Wolowitz, Bernadette, Anu and Koothrappali turn Koothrappali's canceled bachelor party into a couple's trip aboard the "vomit comet."
S2, EP13 "The Friendship Algorithm"
Sheldon develops a scientific procedure for making friends; Kripke controls a new supercomputer.
S2, EP14 "The Financial Permeability"
Sheldon's solution to Penny's financial difficulty leads to a confrontation between Leonard and Penny's ex-boyfriend.
S2, EP15 "The Maternal Capacitance"
Leonard and Penny are drawn together after a disastrous visit from Leonard's mother (Christine Baranski).
S7, EP9 "The Thanksgiving Decoupling"
When the gang decides to spend Thanksgiving at Mrs. Wolowitz's house, Sheldon protests; Leonard and Penny deal with an error from her past.
S7, EP8 "The Itchy Brain Simulation"
When a mistake comes to light, Sheldon makes Leonard walk a mile in his shoes; Penny decides to confront Raj's ex.
S7, EP7 "The Proton Displacement"
When Professor Proton asks Leonard for help with an experiment, Sheldon retaliates by befriending Proton's rival, Bill Nye.
S7, EP6 "The Romance Resonance"
Sheldon's latest scientific breakthrough leaves him feeling like a fraud; a romantic gesture between Howard and Bernadette causes Penny to up her game with Leonard.