
Dr. Temperance Brennan, a forensic anthropologist who works at the Jeffersonian Institution and also writes books, has an impressive ability to read clues from victims' bones. Consequently, law enforcement calls her to assist with investigations when remains are so badly decomposed, burned or destroyed that standard identification methods are useless. Brennan is teamed with Special Agent Seeley Booth, a former Army sniper, who mistrusts science and scientists when it comes to solving crimes but who has developed respect for Brennan, both professionally and personally.

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When a female roller derby skater is killed and dismembered, Angie goes undercover to help solve the case; Cam tries to learn more about Booth's secretive hospital appointments.
While in the hospital after being shot at the lab, Brennan struggles with visions of her mother that defy her usual logic; evidence may link Brennan's attacker to the Jeffersonian.
As the team investigates the death of a seemingly innocent 15-year-old boy, they learn that he was involved in illegal activity.
When a well-educated but eccentric intern starts working at the Jeffersonian, Brennan tries to be more open-minded about scientific questions.