
Dr. Temperance Brennan, a forensic anthropologist who works at the Jeffersonian Institution and also writes books, has an impressive ability to read clues from victims' bones. Consequently, law enforcement calls her to assist with investigations when remains are so badly decomposed, burned or destroyed that standard identification methods are useless. Brennan is teamed with Special Agent Seeley Booth, a former Army sniper, who mistrusts science and scientists when it comes to solving crimes but who has developed respect for Brennan, both professionally and personally.

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When a corpse is discovered in the woods, the team considers two families involved in a nearly century-long feud; Brennan is apprehensive when her father (Ryan O'Neal) offers to baby-sit for her daughter.
While in Los Angeles to consult on a film based on her latest book, Brennan discovers the prop cadaver being used is a murder victim; Booth gets a job offer; embarrassing information about Cam's past comes out.
When a past suspect is back in court on appeal, Booth and Brennan work to prove he is guilty once and for all; Brennan becomes a suspect.
After Brennan is accused of murder, her father (Ryan O'Neal) helps her hide from the FBI; Booth and the team think an evil tech genius (Andrew Leeds) manipulated evidence to implicate Brennan.