
Dr. Temperance Brennan, a forensic anthropologist who works at the Jeffersonian Institution and also writes books, has an impressive ability to read clues from victims' bones. Consequently, law enforcement calls her to assist with investigations when remains are so badly decomposed, burned or destroyed that standard identification methods are useless. Brennan is teamed with Special Agent Seeley Booth, a former Army sniper, who mistrusts science and scientists when it comes to solving crimes but who has developed respect for Brennan, both professionally and personally.

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Human remains from a 150-year-old slave ship surface; the investigation leads Booth and Brennan to a cruise where a murder victim is seen moments before his death.
An event for a candy maker (Wayne Knight) turns bitter when human remains are discovered in the world's largest chocolate bar; Cam struggles with her daughter's decision to attend a college that fails to meet her high standards.
Brennan and Booth investigate a crime scene where a human carcass has melted to the dashboard of a charred truck; Sweets tries to keep his feelings for Daisy from interfering while helping her pass a government psychological evaluation.
A brilliant and career-driven surgeon is found dead in a rough neighborhood; a new friend helps Brennan make a discovery about herself.